日誌
乾癬治療總整理(建議善存+500毫克維他命C+高劑量維他命E+每朝健康綠茶) ... ...
導讀：
嚴重乾癬關節變形，怎麼治？(主要缺鎂，建議善存+多喝豆漿+多喝茶。)
乾癬（英語：psoriasis，學名為銀屑病，又稱「白疕」或「牛皮癬」）
是一種慢性皮膚疾病，主要特色是在身上出現一塊一塊異常的皮膚[1]。
In a prospective dose escalation study, the researchers assessed treatment with human IL-4
in 20 patients with severe psoriasis.
在一項前瞻性劑量遞增研究中，研究人員評估了20例重度牛皮癬患者的人IL-4治療。
They found that within six weeks of starting treatment all patients had decreased
clinical scores
他們發現，在開始治療的六週內，所有患者的臨床評分均下降
Improvements in psoriasis by more than 68 per cent were seen in 15 patients.
15名患者的銀屑病改善率超過68％。
[13]. In psoriasis for example low levels of IL-10 are detectable both in the skin by immunohistochemistry both through direct dosing into the fluid of the psoriatic lesion.
例如，在乾癬中，在皮膚中都可檢測到低水平的IL-10。
小結1：
所以IL-4及IL-10對乾癬是有正面幫助的。
Psoriasis involves hyperproliferation of the keratinocytes in the epidermis,
with an increase in the epidermal cell turnover rate. (See Pathophysiology.)
乾癬涉及表皮中角質形成細胞的過度增殖，並增加表皮細胞周轉率。（請參閱病理生理學。）
Psoriatic plaques are characterized by (1) an abnormal proliferation and differentiation
of keratinocytes leading to epidermal hyperplasia,
(2) dermal infiltration of the dermis by various immune cells, and
(3) increased dermal capillary density, with enhanced permeability in wide-caliber vessels [4].
乾癬斑塊的特徵在於（1）角質形成細胞的異常增殖和分化導致表皮增生;
（2）各種免疫細胞對真皮的真皮浸潤;（3）真皮毛細血管密度增加，大口徑血管的通透性增強 [4]。
老人斑，怎麼治？(建議善存+500毫克維他命C+高劑量維他命E+每朝健康綠茶)
告訴我們：
IFN-γ介導Th-1型炎症和對角質形成細胞的生長抑制。
In addition, CD4+CD25(high) regulatory T-cell (Treg) function appeared to
be impaired in psoriasis.
此外，CD4 + CD25（high）調節性T細胞（Treg）功能似乎在牛皮癬中受損。
抗NMDA受體腦炎，怎麼治？Part-II(建議鎂鋅錳為主，建議善存+多喝豆漿+多喝茶。)
告訴我們：
干擾素-γ(IFN-γ)產生調節性T細胞(Tregs)
IL-10增強人誘導的調節性T細胞的分化。
通過Th2細胞因子IL-4激活幼稚CD4 + CD25 + FOXP3 + Treg的激活
發現IL-2對CD4（+）CD25（+）調節性T細胞的發育和外周擴增至關重要
There are three types of autophagy: macroautophagy, microautophagy, and chaperone-mediated autophagy (Fig. 1).
Psoriasis ...[71], and pathologically characterized by inflammation and epidermal
proliferation.
Several pathogens, such as bacteria, viruses and even fungi, have been linked
to psoriasis [72].
自噬共有三種類型：宏觀自噬，微自噬和伴侶介導的自噬（圖1）。
乾癬... [71]，其病理特徵是炎症和表皮增生。
幾種病原體，如細菌，病毒，甚至真菌，都與乾癬有關[72]。
A study showed that the ratios of Th17 to Treg cells were significantly higher in the patients with psoriasis than those in the normal controls, which demonstrated that the balance between Th17 and Treg plays an important role in the pathogenesis of psoriasis.
As stated above, autophagy was enhanced when Th17 decreased and Treg cells increased.
The ratio of Th17 to Treg cells was elevated in patients with psoriasis; thus,
decreased autophagy could affect psoriasis through Th17 and Treg cells.
一項研究表明，乾癬患者中Th17與Treg細胞的比率明顯高於正常對照組，這表明Th17和Treg之間的平衡在乾癬的發病中起著重要作用。
如上所述，當Th17減少而Treg細胞增加時，自噬被增強。乾癬患者中Th17與Treg細胞的比例升高；因此，自噬減少可能通過Th17和Treg細胞影響乾癬。
Psoriasis is characterized by heavily scaled red plaques. The excessive epithelial
keratinocyte (KC) proliferation and abnormal apoptosis are important features of
psoriasis [88], and inhibition of the excessive proliferation of KCs is an effective treatment method [89].
Studies have recently shown that autophagy deficiency leads to inflammatory cytokine production and cell proliferation in KCs [90].
乾癬的特點是紅色斑塊嚴重。過度的上皮角質形成細胞（KC）增殖和異常凋亡是乾癬的重要特徵[88]，抑制KCs過度增殖是一種有效的治療方法[89]。
最近的研究表明，自噬不足會導致炎症細胞因子的產生和KCs中細胞的增殖[90]。
老人斑，怎麼治？(建議善存+500毫克維他命C+高劑量維他命E+每朝健康綠茶)
告訴我們：
皮膚表面也可以產生自噬作用
自噬調節角蛋白(上皮角質形成細胞)穩態
IFN-γ，IL-2，誘導自噬。
IFN-γ介導對角質形成細胞的生長抑制。
Th17 cells are characterized by production of IL-17
Th17細胞的特徵在於產生IL-17
IL-2 level was negatively correlated with the level of IL-17A.
IL-2水平與IL-17A水平呈負相關。
In contrast, Th17 cell responses have been shown to be inhibited by IL-2.
相反，已顯示Th17細胞反應被IL-2抑制。
More recently, it was found that IFN-γ inhibits IL-17 production.
最近，發現IFN-γ抑制IL-17的產生。
Our results suggest that IFN-γ inhibits the inflammatory response by downregulating
Th17 cell differentiation and IL-17 production.
我們的結果表明，IFN-γ通過下調Th17細胞分化和IL-17產生來抑制炎症反應。
小結2：
由以上可知，IL-2及IFN-r增加自噬、抑制IL-17的產生、增加調節性T細胞(Tregs)，
所以對乾癬是有正面幫助的。
~~~
香港腳治療總整理(建議善存+500毫克維他命C+高劑量維他命E+每朝健康綠茶)
告訴我們：
能提高IL-10的元素：
鎂、鋅、錳、硒、維生素A、維生素D、維生素E、兒茶素、薑黃素、碘、茄紅素
、黃酮類化合物(生物類黃酮、大豆異黃酮)、鞣花酸
能提高IL-2的元素：
鋅、銅、硒、鈣、維生素A、維生素C、維生素E、大豆異黃酮、兒茶素、花青素、茄紅素、多醣體、牛磺酸
能提高IFN-γ的元素：
鋅、硒、錳、維生素A、維生素C、高劑量維生素E、兒茶素、茄紅素、大豆異黃酮、多醣體
能同時提高IL-2+IFN-γ的元素：鋅、硒、維生素A、維生素C、維生素E、兒茶素、大豆異黃酮、茄紅素
能同時提高IL-2+IFN-γ+IL-10的元素：鋅、硒、維生素A、維生素E、兒茶素、大豆異黃酮、茄紅素
總結以上：
建議
一天一粒男性/女性善存
+500毫克維他命C
+高劑量維他命E
+一天兩瓶高兒茶素每朝健康綠茶或茶裏王濃韻(https://yingyang.911cha.com/OWY2.html)
