C9orf72 hypermethylation protects against repeat expansion-associated pathology in ALS/FTD
Promoter hypermethylation of repeat expansion carriers was also associated
with reduced accumulation of RNA foci and dipeptide repeat protein aggregates in human brains.
重複擴增載體的啟動子高甲基化還與人腦中RNA病灶和二肽重複蛋白聚集體的積累減少有關。
These results indicate that C9orf72 promoter hypermethylation prevents
downstream molecular aberrations associated with the hexanucleotide repeat expansion
結果表明C9orf72啟動子高甲基化防止了與六核苷酸重複擴增相關的下游分子畸變
C9ORF72 is attributed to CpG hypermethylaion of promoter (37)
C9ORF72歸因於啟動子的CpG高甲基化（37）
Although CpG methylation is thought to be a negative regulator of gene
transcription, its relationship with cytokine expression remains unclear.
儘管CpG甲基化被認為是基因轉錄的負調節因子，但其與細胞因子表達的關係仍不清楚。
In naïve cells, the CpGs in the promoter regions were methylated largely
in both the IL-4 and IFN-gamma genes.
在幼稚細胞中，啟動子區域中的CpG主要在IL-4和IFN-γ基因中甲基化。
The methylation profile of promoters was affected by vitamin A supplementation
啟動子的甲基化譜受維生素A補充的影響
an emulsion of vitamin A as retinyl ester (RE) or β-carotene (BC).
維生素A乳液作為視黃酯（RE） β-胡蘿蔔素（BC）
In the RE group, hypermethylation of the Rbp4 (at multiple CpGs)
and the Pparg2 (at a specific CpG) promoters and hypomethylation
of the Pcna promoter (at multiple CpGs) was observed
在RE組中，觀察到Rbp4（在多個CpG處）和Pparg2（在特定CpG處）
啟動子的高甲基化和Pcna啟動子的低甲基化（在多個CpG處）
In the BC group, hypomethylation of the Rbp4 and hypermethylation of
the Pcna promoter at distinct CpGs was observed
在BC組中，觀察到Rbp4的低甲基化和Pcna啟動子在不同CpG處的高甲基化
In patients with amyotrophic lateral sclerosis (ALS), serum retinol-binding
protein 4 (RBP4) concentration is inversely associated with the risk
在肌萎縮側索硬化症（ALS）患者中，血清視黃醇結合蛋白4（RBP4）濃度與疾病的風險呈負相關。
所以維它命A有助於C9orf72啟動子高甲基化防止了六核苷酸重複擴增