日誌
骨髓纖維化，怎麼治？Part-III(紅血球增多症的缺銅，血小板增多症的缺鋅) ... ...
目前骨髓纖維化發生可以分為兩種，一種是原發性骨髓纖維化；另一種為繼發性骨髓纖維化，例如：真性紅血球增多症後的骨髓纖維化或血小板增多症後的骨髓纖維化。
一、紅血球增多症的骨髓纖維化缺銅
台中市一名65歲男子多年健檢唯獨紅血球指數升高(紅血球變多)，檢查發現脾臟已腫大，診斷為骨髓纖維化。
節錄自https://ndu(的相反).com/news/story/7266/3195039
節錄自https://ndu(的相反).com/news/story/7266/3195039
Obtained results showed that the level of Potassium, Calcium and zinc in polycythemic subjects
were significantly higher than that of healthy subjects (p<0.05)
結果顯示，紅細胞增多症患者的鉀，鈣和鋅水平顯著高於健康對照組（p <0.05）
, while serum iron, Copper in polycythemic subjects were significantly lower than that of healthy subjects.
而血清鐵，銅在紅細胞增多症患者中顯著低於健康對照組。
Magnesium level shows no significant difference between two studied groups.
兩個研究組之間鎂水平顯示沒有顯著的差異
節錄自http://iqjmc.net/wp-content/uploads/2016/10/bagmed11521-24.pdf
were significantly higher than that of healthy subjects (p<0.05)
結果顯示，紅細胞增多症患者的鉀，鈣和鋅水平顯著高於健康對照組（p <0.05）
, while serum iron, Copper in polycythemic subjects were significantly lower than that of healthy subjects.
而血清鐵，銅在紅細胞增多症患者中顯著低於健康對照組。
Magnesium level shows no significant difference between two studied groups.
兩個研究組之間鎂水平顯示沒有顯著的差異
節錄自http://iqjmc.net/wp-content/uploads/2016/10/bagmed11521-24.pdf
Corroborative Features
確定特徵
Polycythemia.
紅細胞增多症。
Manganese induces expression of the gene encoding erythropoietin
錳誘導編碼促紅細胞生成素的基因的表達
Some individuals studied have been found to have elevated erythropoietin levels
研究發現一些個體的促紅細胞生成素水平升高
節錄自https://www.ncbi.nlm.nih.gov/books/NBK100241/
鋅缺乏會降低血漿促紅細胞生成素(EPO)
維生素A治療增加紅細胞生成素（EPO）的產生
節錄自http://blog.eyny.com/blog-5788411-758378.html
確定特徵
Polycythemia.
紅細胞增多症。
Manganese induces expression of the gene encoding erythropoietin
錳誘導編碼促紅細胞生成素的基因的表達
Some individuals studied have been found to have elevated erythropoietin levels
研究發現一些個體的促紅細胞生成素水平升高
節錄自https://www.ncbi.nlm.nih.gov/books/NBK100241/
鋅缺乏會降低血漿促紅細胞生成素(EPO)
維生素A治療增加紅細胞生成素（EPO）的產生
節錄自http://blog.eyny.com/blog-5788411-758378.html
二、血小板增多症的骨髓纖維化缺鋅
Thrombocythemia (THROM-bo-si-THE-me-ah) and thrombocytosis (THROM-bo-si-TO-sis) are conditions in which your blood has a higher than normal number of platelets (PLATE-lets).
血小板增多症（THROM-bo-si-THE-me-ah）和血小板增多症（THROM-bo-si-TO-sis）是血液中血小板數量比正常數量更多的病症（PLATE-let）。
節錄自https://www.nhlbi.nih.gov/health-topics/thrombocythemia-and-thrombocytosis
血小板增多症（THROM-bo-si-THE-me-ah）和血小板增多症（THROM-bo-si-TO-sis）是血液中血小板數量比正常數量更多的病症（PLATE-let）。
節錄自https://www.nhlbi.nih.gov/health-topics/thrombocythemia-and-thrombocytosis
促血小板生成素（英語：Thrombopoietin，縮寫爲「THPO」），亦作「巨核細胞生長衍生因子」（MGDF），是一種人體內由促血小板生成素（THPO）基因編碼的類激素。
節錄自https://zh.wikipedia.org/zh-tw/促血小板生成素
megakaryocyte growth and development factor (MGDF)
節錄自https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904343/
節錄自https://zh.wikipedia.org/zh-tw/促血小板生成素
megakaryocyte growth and development factor (MGDF)
節錄自https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904343/
zinc supplemented swimming group (Group 2, n=10)
鋅補充游泳組（2組）
Platelet counts in group 2 was significantly lower than in all other groups (p<0.05).
組2中血小板計數顯著低於其他所有組（p <0.05）
節錄自https://www.ncbi.nlm.nih.gov/pubmed/12903911
zinc deficiency reduced granule substances without changing the numbers of megakaryocytes and platelets.
缺鋅會減少顆粒物質而不會改變巨核細胞和血小板的數量。
Conclusion
zinc increased HDL-c levels and decreased platelet count
鋅增加HDL-c水平和降低血小板計數
節錄自https://www.scitechnol.com/peer-review/zinc-supplementation-increases-food-intake-and-hdlc-and-decreases-platelets-in-healthy-children-H6DF.php?article_id=4047
鋅補充游泳組（2組）
Platelet counts in group 2 was significantly lower than in all other groups (p<0.05).
組2中血小板計數顯著低於其他所有組（p <0.05）
節錄自https://www.ncbi.nlm.nih.gov/pubmed/12903911
zinc deficiency reduced granule substances without changing the numbers of megakaryocytes and platelets.
缺鋅會減少顆粒物質而不會改變巨核細胞和血小板的數量。
Conclusion
zinc increased HDL-c levels and decreased platelet count
鋅增加HDL-c水平和降低血小板計數
節錄自https://www.scitechnol.com/peer-review/zinc-supplementation-increases-food-intake-and-hdlc-and-decreases-platelets-in-healthy-children-H6DF.php?article_id=4047
總結以上：
紅血球增多症造成的骨髓纖維化缺銅
而血小板增多症造成的骨髓纖維化應該是缺鋅
相關文章：
骨髓纖維化，怎麼治？(應該是缺錳，建議喝茶。)
骨髓纖維化，怎麼治？Part-II(喝豆漿補充銅、錳，喝茶補充錳都有幫助)
