VK2 inhibited the basal and TPA-induced expression of MMP-1, -3 and -7 at the transcriptional
維它命K2抑制MMP-7
Additionally MMP-2 and 9are minimized via either vitamin K alone or vitamin K with...
維它命K降低MMP-9
regulating expressions of cartilage vitamin K dependent gamma-glutamyl carboxylase (GGCX)
effectively improve pathological changes of cartilage cells in KOA rabbits,
which may be associated with their actions in up-regulating the expression of cartilage GGCX protein
and lowering the levels of serum ucMGP content and cartilage MMP 13 protein expression.
調節軟骨維生素K依賴性γ-谷氨酰羧化酶(GGCX)的表達
上調維生素K依賴性γ-谷氨酰羧化酶(GGCX)的表達
同時就能降低MMP-13的表達
含維生素K食物
中等維他命 K 含量、高維他命 K 含量食物
維它命C可以減少MMP-9(metalloproteinase-9)的產生
This study showed that MMP-1, MMP-3, and MMP-13 were remarkably increased,
However, vitamin C can block the changes even if their changes are in mass.
維它命C可以阻擋MMP-13變多
餵食 Vit. C 可預防 UVB 照射導膠原蛋白的裂解;而其分子機制是經由抑制 MMP- 1、MMP-2、MMP-9 及 MMP-13 的活性,
同時活化基質金屬蛋白酶組織抑制劑-1(tissue inhibitor of metalloproteinase, TIMP-1)來達到抑制膠原蛋白分解。
節錄自http://webcache.googleusercontent.com/search?
q=cache:CYYDtU2LgMkJ:ir.lib.csmu.edu.tw:8080/ir/bitstream/310902500/13648/2/
維生素D(3)顯著降低了MMP-7和MMP-9,並增加了TIMP-1(p = 0.005)水平。
基質金屬蛋白酶13(Mmp13,膠原酶-3)在骨代謝和礦物質穩態中起重要作用。 它
由許多因素調節,包括BMP-2,甲狀旁腺激素和1α,25-二羥基維生素D3(1,25(OH)2D3)
Treatment with 1,25(OH)2D3 and the 20(OH)D3 analog reduced MMP-13 expression by 62% and 60%
維它命D的活性形式可以降低MMP-13表達